个人简介
厦门大学生命科学专业学士、硕士，香港中文大学公共卫生专业博士。中山大学“百人计划”引进人才，获得广州市“珠江科技新星”、广东省自然科学基金“杰出青年”基金。
研究方向：消化系统肿瘤微生态及表观遗传调控。在相关领域发表SCI文章79篇，其中31篇作为第一或通讯作者，发表在Gut、Hepatology、Cell Reports Medicine等领域权威期刊。论文被引用次数超过4400次，H指数33。主持科研项目8项，包括3项国然面上项目,1项国自然青年项目和1项广东省自然杰出青年基金项目。相关成果申请国内外发明专利10项，8项已获得授权。
科研项目
国家自然科学基金面上项目，2024.01.01–2027.12.31，主持
国家自然科学基金面上项目，2018.01.01–2021.12.31，主持
广东省自然科学基金“杰出青年基金”项目，2015.08.01-2019.7.31，主持
国家自然科学基金面上项目，2014.01.01-2017.12.31，主持
国家自然科学基金青年项目，2013.01.01–2015.12.31，主持
代表性成果
- Zhao Y#, Li S#, Zhu L#, Huang M, Xie Y, Song X, Chen Z, Lau HC, Sung JJ, Xu LX*, Yu J*, Li XX*. Personalized drug screening using patient-derived organoid and its clinical relevance in gastric cancer. Cell Rep Med. 2024; Epub ahead of print.
- Chen W#, Jiang X#, Liang W#, Bai H#, Xu M, Liu Z, Yi L, Liu Y, Huang Y, Zhang Y, Xu L, Xie B, Zhang N, Yu J, Lu J*, Xiao H*, Li XX*. SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids. Research. 2024;7:0376.
- Li M, Wang L, Cong L, Wong CC, Zhang X, Chen H, Zeng T, Li B, Jia X, Huo J, Huang Y, Ren X, Peng S, Fu G, Xu L, Sung JJ, Kuang M, Li XX*, Yu J*. Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma. Hepatology. 2024; 79(3):560-574.
- Chen M#, Fang Y#, Liang M, Zhang N, Zhang X, Xu L, Ren X, Zhang Q, Zhou Y, Peng S, Yu J, Zeng J*, Li XX*. The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma. J Transl Med. 2023;21(1):276.
- Ren XX, Huang ML, Weng WX, Xie YB, Wu YF, Zhu SH, Zhang Y, Li DM, Lai JM, Shen SL, Lin J, Kuang M, Li XX*, Yu J*, Xu LX*. Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application. Cell Rep Med. 2023;4(11).
- Zhang XY#, Liu ZX#, Zhang YF#, Xu LX, Chen MK, Zhou YF, Yu J, Li XX*, Zhang N*. SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival. Cell Biosci. 2023;13(1):63.
- Zeng B#, Liu Z#, Zhu H, Zhang X, Yang W, Li XX*, Cheng C*. CircRNA_2646 functions as a ceRNA to promote progression of esophageal squamous cell carcinoma via inhibiting miR-124/PLP2 signaling pathway. Cell Death Discov. 2021;7(1):99.
- Zhang Q#, Yu K#, Li S, Zhang X, Zhao Q, Zhao X, Liu Z, Cheng H, Liu ZX*, Li XX*. gutMEGA: a database of the human gut MEtaGenome Atlas. Brief Bioinform 2021; 22(3):bbaa082.
