罗镇华
研究员，博士生导师
研究方向：肝脏损伤修复机制、肝脏胆管疾病系统生物学和泛癌症基因组学
电子邮件： luozhh35@mail.sysu.edu.cn
个人简介

国家级青年人才项目入选者，中山大学“百人计划”引进人才，博士和硕士研究生导师。 美国肝脏病学研究学会（AASLD）会员，曾在美国辛辛那提儿童医院从事博士后研究工作4年。主要研究方向为肝脏胆管疾病系统生物学、泛癌症基因组学等。研究方向：运用临床数据分析、生物信息学和3D培养类器官实验生物学等交叉学科手段， 研究肝脏损伤修复机制、肝脏胆管疾病的分子标志物、病理机制和治疗方法。此外，课题组还致力于泛癌症、衰老和端粒调控网络的生物信息多组学分析。多项代表作发表于Gastroenterology、Hepatology、Molecular Cancer、Briefings in Bioinformatics和Aging Cell 等国际知名SCI期刊杂志。主持多项国家自然科学基金和广东省自然基金项目。

代表性成果

第一作者或通讯作者文章：

  1. Man-Huan Xiao#, Dong Ma#, Sihan Wu#, Zaoli Huang#, Peishi Liang, Huadong Chen, Zhihai Zhong, Wei Li, Fen Wang, Yanlai Tang, Juncheng Liu, Hong Jiang*, Xuyang Feng*, Zhenhua Luo*. Integrative single-cell and spatial transcriptomic analyses identify a pathogenic cholangiocyte niche and TNFRSF12A as therapeutic target for biliary atresia. (2024) Hepatology. 2025 Apr 1;81(4):1146-1163.

  2. Man-Huan Xiao, Sihan Wu, Peishi Liang, Dong Ma, Jiang Zhang, Huadong Chen, Zhihai Zhong, Juncheng Liu, Hong Jiang*, Xuyang Feng*, Zhenhua Luo*. Mucosal-associated invariant T cells promote ductular reaction through amphiregulin in biliary atresia. (2024) eBioMedicine. 103:105138 

  3. Abigail E Russi#, Pranavkumar Shivakumar#, Zhenhua Luo*, Jorge A Bezerra*. Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia. (2023) Hepatology. 78(4):1035-1049

  4. Huan Wang#, Tengfei Ma#, Xiaotong Zhang, Wei Chen, Yina Lan, Guotao Kuang, Shih-Jui Hsu, Zibin He, Yuxi Chen, Jason Stewart, Anukana Bhattacharjee, Zhenhua Luo*, Carolyn Price*, Xuyang Feng*. CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension. (2023) Nucleic Acids Research. 51(10):4914-4928

  5. Huiya Xu, Wei Li, Chongmei Zhu, Na Cheng, Xiaoxia Li, Fengyun Hao, Junfeng Zhu, Liyun Huang, Ran Wang, Liantang Wang*, Zhenhua Luo*, Fen Wang*. Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney. (2022) Journal of Pathology. 257(1):53-67.

  6. Zhenhua Luo#, Pranavkumar Shivakumar#, Reena Mourya, Sridevi Gutta and Jorge A. Bezerra. Gene expression signatures associated with survival times of pediatric patients with biliary atresia identify potential therapeutic agents. (2019) Gastroenterology. 157(4)：1138-1152 

  7. Zhenhua Luo, Anil G Jegga and Jorge A. Bezerra. Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies. (2018) Hepatology. 67: 676-689. doi:10.1002/hep.29504

  8. Zhenhua Luo#, Weixu Wang#, Feng Li#, Zhou Songyang, Xuyang Feng, Changchang Xin, Zhiming Dai* and Yuanyan Xiong*. Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes. (2019) Molecular Cancer. 18(1):106.

  9. Zhenhua Luo, Weijin Liu, Panpan Sun, Feng Wang, Xuyang Feng. Pan-cancer analyses reveal regulation and clinical outcome association of the shelterin complex in cancer. (2021) Briefings in Bioinformatics. Bbaa441 

  10. Zhenhua Luo, Xuyang Feng, Haoli Wang, Weiyi Xu, Yong Zhao, Wenbin Ma, Dan Liu, Songshan Jiang, Junjiu Huang* and Zhou Songyang*. MiR-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression. (2015) Aging Cell 14(3): 391–399. 

编审期刊/学术兼职/奖励荣誉

1.美国肝脏病学研究学会2018年儿科研究奖