2021年于美国堪萨斯大学医学中心获博士学位；2021-2022于美国美国堪萨斯大学医学中心接受博士后训练；2022年经中山大学“百人计划”中青年杰出人才项目引进，入职中山一院精准医学研究院。主要研究自噬在酒精性肝病、药源性肝损伤和肝癌等相关疾病病理发生发展中的作用、调控机制、及潜在治疗靶点。代表性论文发表在Gastroenterology, Journal of Hepatology, Hepatology, Autophagy， APSB等国际知名学术期刊。

1、自噬在酒精性和非酒精性肝病、肝硬化、以及肝癌等肝脏重大疾病中作用；

2、慢性肝脏疾病病理发展中，肝脏中细胞间相互作用

课题组长期招收博士后、博士/硕士研究生和研究助理，欢迎对自噬或肝脏疾病有兴趣的同学加入。

1. Chao X*, Niu M, Wang S, Ma X, Yang X, Sun H, Hu X, Wang H, Zhang L, Huang R, Xia M, Ballabio A, Jaeschke H, Ni HM, Ding WX*. High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice. Acta Pharmaceutica Sinica B. 2024; 14(1): 190-206. (封面文章)
2. Chao X, Wang S, Fulte S, Ma X, Ahamed F, Cui W, Liu Z, Rulicke T, Zatloukal K, Zong WX, Liu W, Ni HM*, Ding WX*. Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis. Hepatology. 2023; 78(2): 503-517. (封面文章)
3. Chao X^#, Wang S^#, Fulte S, Ma X, Ahamed F, Cui W, Liu Z, Rulicke T, Zatloukal K, Zong WX, Li W, Ni HM, Ding WX*. Hepatocytic p62/Sqstm1 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy. J Hepatol. 2022; 76(3):639-651.
4. Chao X, Ni HM, Ding WX*. An unexpected tumor suppressor role of SQSTM1/ p62 in liver tumorigenesis. Autophagy. 2022; 18(2):459-461.
5. Wang S^#, Chao X^#, Jiang X, Wang T, Rodriguez Y, Yang L, Pacher P, Ni HM, Ding WX*. Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice. Autophagy. 2021. doi: 10.1080/15548627.2021.1990672.
6. Chao X, Wang S, Hlobik M, Ballabio A, Ni HM, Ding WX*. Loss of hepatic transcription factor EB attenuates alcohol-associated liver carcinogenesis. Am J Pathol. 2022; 192(1):87-103.
7. Chao X, Wang S, Yang L. Ni HM, Ding WX*. Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. Alcohol Clin Exp Res. 2021; 45(10): 1950-1964.
8. Ni HM, Chao X, Yang H, Deng F, Wang S, Bai Q, Qian H, Cui Y, Cui W, Shi Y, Zong WX, Wang Z, Yang L, Ding WX*. Dual roles of mTOR in regulating liver injury and tumorigenesis in autophagy defective mouse liver. Hepatology. 2019; 70(6):2142-2155.
9. Chao X^#, Wang S^#, Zhao K, Li Y, Williams J, Li T, Chavan H, Krishnamurthy P, He X, Li L, Ballabio A, Ni HM*, Ding WX*. Impaired TFEB-mediated lysosome biogenesis and autophagy promote chronic ethanol-induced liver injury and steatosis in mice. Gastroenterology. 2018,155(3):865-879.
10. Chao X, Ni HM, Ding WX*. Insufficient autophagy: a novel autophagic flux scenario uncovered by impaired liver TFEB-mediated lysosomal biogenesis from chronic alcohol-drinking mice. Autophagy. 2018, 14(9):1646-1648.