朱亦君
副研究员，硕士生导师
研究方向：功能代谢组学，微生物群落结构与功能
电子邮件： zhuyj67@mail.sysu.edu.cn
个人简介

副研究员，硕士生导师，2017年毕业于英国华威大学获博士学位，2017年至2020年于美国克利夫兰诊所从事博士后研究员工作，2020年加入中山大学附属第一医院精准医学研究院。研究成果发表在Cell Host & Microbe, PNAS, Microbiome, Journal of Crohn’s and Colitis等期刊。

团队介绍

我们的课题组采用跨学科策略，结合分析化学、生物信息学和微生物生态学，深入研究肠道微生物群落的功能及其对人体健康的重要作用。研究对象从微生物基因和蛋白质的分子层面，单个细菌个体，扩展到整个微生物群落的交互网络，全面揭示了微生物之间以及与宿主间的复杂关系。

代表性成果
  1. Luo W*, Zhao M*, Dwidar M, Gao Y, Xiang L, Wu X, Medema MH, Xu S, Li X, Schäfer H, Chen M#, Feng R#, Zhu Y#. Microbial assimilatory sulfate reduction-mediated H2S: an overlooked role in Crohn's disease development. Microbiome. 2024 Aug 16;12(1):152.
  2. Xiang L*, Zhuo S*, Luo W, Tian C, Xu S, Li X, Zhu Y#, Feng R#, Chen M#. Decoding polyphenol metabolism in patients with Crohn's disease: Insights from diet, gut microbiota, and metabolites. Food Res Int. 2024 Sep;192:114852.
  3. Xu S*, Li X*, Zhang S, Qi C, Zhang Z, Ma R, Xiang L, Chen L, Zhu Y, Tang C, Bourgonje AR, Li M, He Y, Zeng Z, Hu S#, Feng R#, Chen M#. Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study. BMC Med. 2023 May 11;21(1):179.
  4. Feng R*, Tian Z*, Mao R, Ma R, Luo W, Zhao M, Li X, Liu Y, Huang K, Xiang L, Zhuang X, Huo B, Yu T, Chen S#, Chen M#, Zhu Y#. Gut Microbiome-Generated Phenylacetylglutamine from Dietary Protein is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Model Possibly via Platelet Activation. J Crohns Colitis. 2023 Nov 24;17(11):1833-1846.
  5. Ma R*, Zhu Y*, Li X, Hu S, Zheng D, Xiong S, Xu S, Xiang L, Zhao M, Tang C, Zeng Z, Chen M#, Feng R#. A Novel Serum Metabolomic Panel for the Diagnosis of Crohn's Disease. Inflamm Bowel Dis. 2023 Oct 3;29(10):1524-1535.
  6. Zhu Y*, Dwidar M*, Nemet I, Buffa JA, Sangwan N, Li XS, Anderson JT, Romano KA, Fu X, Funabashi M, Wang Z, Keranahalli P, Battle S, Tittle AN, Hajjar AM, Gogonea V, Fischbach MA, DiDonato JA, Hazen SL. Two distinct gut microbial pathways contribute to meta-organismal production of phenylacetylglutamine with links to cardiovascular disease. Cell Host Microbe. 2023 Jan 11;31(1):18-32.e9.
  7. Tian Z*, Zhuang X*, Zhuo S*, Zhu Y, Hu S, Zhao M, Tang C, Zhang Z, Li X, Ma R, Zeng Z, Feng R#, Chen M#. Dietary inflammatory potential mediated gut microbiota and metabolite alterations in Crohn's disease: A fire-new perspective. Clin Nutr. 2022 Jun;41(6):1260-1271.
  8. Tian Z*, Zhuang X*, Zhao M, Zhuo S, Li X, Ma R, Li N, Liu C, Zhu Y, Tang C, Feng R#, Chen M#. Index-Based Dietary Patterns and Inflammatory Bowel Disease: A Systematic Review of Observational Studies. Adv Nutr. 2021 Dec 1;12(6):2288-2300.
  9. Lidbury I*, Kröber E*, Zhang Z, Zhu Y, Murrell JC, Chen Y#, Schäfer H#. A mechanism for bacterial transformation of dimethylsulfide to dimethylsulfoxide: a missing link in the marine organic sulfur cycle. Environ Microbiol. 2016 Sep;18(8):2754-66
  10. Zhu Y, Ksibe AZ, Schafer H, Blindauer CA, Bugg TD, Chen Y. O2‐independent demethylation of trimethylamine N‐oxide by Tdm of Methylocella silvestris. FEBS J. 2016 Nov;283(21):3979-93.
  11. Zhu Y*, Jameson E*, Crosatti M*, Schafer H, Rajakumar K, Bugg TD, Chen Y. Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. PNAS. 2014 Mar 18;111(11):4268-73.
  12. Zhu Y, Jameson E, Parslow RA, Lidbury I, Fu T, Dafforn TR, Schafer H, Chen Y. Identification and characterization of trimethylamine N‐oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. Environ Microbiol. 2014 Oct;16(10):3318-30.