博士毕业于清华大学与北京生命科学研究所联合培养项目。2015–2021年在美国康奈尔大学医学院免疫学系开展博士后研究，聚焦肿瘤微环境中的免疫稳态与免疫耐受机制，并探索肿瘤靶向免疫药物开发。近五年以第一或通讯作者在 Science Advances、Nature Communications、Cancer Research、Advanced Science 等国际高水平期刊发表多篇论文，研究成果累计引用4300余次，并获国际专利1项。2021年9月通过“百人计划”引进至中山大学附属第一医院精准医学研究院。当前课题组研究聚焦于驱动基因突变与免疫失调在胃肠道肿瘤发生发展中的作用机制，并开展创新抗肿瘤疗法的开发与转化。
蛋白质翻译后修饰调控肿瘤进展及重塑肿瘤微环境的机制
胃肠道肿瘤转移与耐药机制及生物标志物驱动的精准治疗
肿瘤微环境中新型免疫调控分子的鉴定与治疗开发
国家自然科学基金青年科学基金项目（82303923）2024.01-2026.12，主持
广东省自然科学基金项目面上项目 2024.01-2026.12，主持
课题组现有博士生、硕士生及博士后多名，依托中山大学附属第一医院精准医学研究院科研平台，与医院临床科室深度协作，并与国内外专家保持长期交流。团队注重培养成员的独立科研思维与执行力，秉持“授人以渔，教学相长”的理念，激发团队成员对科学问题的好奇心和探索精神，营造积极向上的科研氛围。欢迎富有科研热情、希望投身肿瘤转化医学研究的研究生加入。
1. Wu X, Huang S, Gao J, Huang S, Chen L, Zhao Z, Pu R, Ma X, Liu X*, He W*, Song M*. AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration. Sci. Adv. 2025 Aug 22: 10.1126/sciadv. adv6937.
2. Song M #, Zhang L #, Dai X #, Ji S #, Shen J*, He W*. Beyond polarization: macrophage senescence in immunoregulation and cancer therapy. Int. J. Biol. Sci. 2025 Jun 23;21(10):4312-4333
3. Song M*, Huang S, Wu X, Zhao Z, Liu X, Wu C, Wang M, Gao J, Ke Z, Ma X, He W*. UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SlC7A11 signaling. Redox Biol. 2024 Sep 10:76:103349.
4. Di Y, Zhang X, Wen X, Qin J, Ye L, Wang Y, Song M*, Wang Z*, He W*. MAPK signaling-mediated RFNG phosphorylation and nuclear translocation restrain oxaliplatin-induced apoptosis and ferroptosis. Adv Sci (Weinh). 2024 Aug 9: e2402795.
5. Chen L, Huang S, Wu X, He W*, Song M*. Serotonin signaling in cancer: Emerging mechanisms and therapeutic opportunities. Clin Transl Med. 2024 Jul;14(7): e1750.
6. Gao J, Wu X, Huang S, Zhao Z, He W*, Song M*. Novel insights into anticancer mechanisms of elesclomol: More than a prooxidant drug. Redox Biol. 2023 Nov: 67:102891.
7. Song M, OO Yeku, Rafiq S, Purdon T, Zhu L, Zhang T, Dong X, Mai J, Shen H, Nixon B, Li M, Brentjens R, Ma X. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nat Commun. 2020 Dec 8;11(1):6298.
8. Song M, Wang C, Wang H, Zhang T, Li J, Benezra R, Chouchane L, Cui X, Sun Y, Ma X. Targeting Ubiquitin Protein Ligase E3 Component N Recognin 5 in Cancer Cells Induces a CD8+ T cell Mediated Immune Response. Oncoimmunology. 2020 Apr 14;9(1):1746148.
9. Song M #, Sun Y, He W, Xu G, Jing Z, Li W #. Silencing retinoid X receptor alpha enhances early Hepatitis B virus infection in cultures. J Virol. 2018 Mar 28;92(8): e01771-17.
10. Liao L *, Song M *, Li X, Tang L, Zhang T, Zhang L, Pan Y, Chouchane L, Ma X. E3 ubiquitin ligase UBR5 drives the growth and metastasis of triple negative breast cancer. Cancer Res. 2017 Apr 15;77(8):2090-2101.
