
博士毕业于清华大学-北京生命科学研究所联合培养项目。2015-2021年于康奈尔大学医学院免疫学系从事博士后研究工作,主要研究方向为肿瘤微环境中免疫稳态、免疫耐受形成和调控的机制,并关注恶性肿瘤靶向免疫药物开发。近五年研究成果以第一作者或通讯作者身份发表在Nature Communications、Cancer Research、Redox Biology等国际知名期刊,以合作作者身份发表在Nature Biotechnology等期刊,总引用超过3500次,申请国际专利一项。2021年9月通过 “百人计划”项目引进中山大学附属第一医院精准医学研究院。当前课题组研究方向聚焦在理解异常基因突变与免疫失调驱动胃肠道肿瘤发生发展的作用机理,并基于研究成果进行科研转化,开发创新性的抗肿瘤疗法。
研究方向
蛋白质泛素化修饰调控肿瘤发生发展及重塑肿瘤微环境的机制研究
胃肠道肿瘤转移及耐药的分子机制和基于生物标志物的精准治疗
肿瘤微环境中免疫细胞功能调控新分子的鉴定及治疗开发
国家自然科学基金青年科学基金项目(82303923)2024.01-2026.12,主持
广东省自然科学基金项目面上项目 2024.01-2026.12,主持
课题组现由多名博士生、硕士生和科研助理组成。依托中山大学附属第一医院精准医学研究院科研平台,与医院临床科室深度协作,同时与领域内多名专家建立长期稳定的交流合作关系。课题组重视培养学生独立科研思维能力和高效执行力,秉持“授人以渔,教学相长”的理念激发团队成员对科学问题的好奇心和探索精神。团队氛围融洽,成员之间互爱互助,期待富有科研热情的研究生加入我们。
1. Song M*, Huang S, Wu X, Zhao Z, Liu X, Wu C, Wang M, Gao J, Ke Z, Ma X, He W*. UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SlC7A11 signaling. Redox Biol. 2024 Sep 10:76:103349.
2. Di Y, Zhang X, Wen X, Qin J, Ye L, Wang Y, Song M*, Wang Z*, He W*. MAPK signaling-mediated RFNG phosphorylation and nuclear translocation restrain oxaliplatin-induced apoptosis and ferroptosis. Adv Sci (Weinh). 2024 Aug 9: e2402795.
3. Chen L, Huang S, Wu X, He W*, Song M*. Serotonin signaling in cancer: Emerging mechanisms and therapeutic opportunities. Clin Transl Med. 2024 Jul;14(7): e1750.
4. Gao J, Wu X, Huang S, Zhao Z, He W*, Song M*. Novel insights into anticancer mechanisms of elesclomol: More than a prooxidant drug. Redox Biol. 2023 Nov: 67:102891.
5. Wu X, Huang S, He W*, Song M*. Emerging insights into mechanisms of transtuzumab resistance in HER2-positive cancers. Int. Immunopharmacol. 2023 Sep: 122:110602.
6. Song M, OO Yeku, Rafiq S, Purdon T, Zhu L, Zhang T, Dong X, Mai J, Shen H, Nixon B, Li M, Brentjens R, Ma X. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nat Commun. 2020 Dec 8;11(1):6298.
7. Song M, Wang C, Wang H, Zhang T, Li J, Benezra R, Chouchane L, Cui X, Sun Y, Ma X. Targeting Ubiquitin Protein Ligase E3 Component N Recognin 5 in Cancer Cells Induces a CD8+ T cell Mediated Immune Response. Oncoimmunology. 2020 Apr 14;9(1):1746148.
8. Song M #, Sun Y, He W, Xu G, Jing Z, Li W #. Silencing retinoid X receptor alpha enhances early Hepatitis B virus infection in cultures. J Virol. 2018 Mar 28;92(8): e01771-17.
9. Liao L *, Song M *, Li X, Tang L, Zhang T, Zhang L, Pan Y, Chouchane L, Ma X. E3 ubiquitin ligase UBR5 drives the growth and metastasis of triple negative breast cancer. Cancer Res. 2017 Apr 15;77(8):2090-2101.