个人简介
副研究员，硕士生导师，2022年中山大学百人计划引进人才。2015年在香港大学取得博士学位，随后在香港大学从事博士后研究工作。研究利用单细胞测序（Single cell sequencing）和体内谱系示踪（Lineage tracing）技术，阐明肝癌干细胞在肝癌发生、发展、转移、抗药和复发中的作用。代表性论文发表在Gut、Nature Communications、Hepatology等知名期刊。
研究方向
1. 肝癌干细胞相关药物靶点及分子调控机制；
2. 肝癌干细胞的异质性及其与肿瘤微环境的相互作用；
3. 肿瘤类器官辅助基础及临床转化研究。
科研项目
1. 2024-2027，国家自然科学基金面上项目， SPINK1蛋白介导肝癌干细胞对化疗药物介入治疗抵抗的机制研究，主持。
2. 2020-2023，国家自然科学基金青年科学基金项目，肝癌干细胞特异性分泌蛋白SPINK1在调控肿瘤相关巨噬细胞的作用和机制研究，主持。
3. 2017-2018，香港食物及卫生局研究处, 医疗卫生研究基金，肝癌类器官模型建立及应用的先导性研究，主持。
代表性成果
- KF Man†, L Zhou†, YT Lam, J Yu, JP Yun, XY Guan, M Liu, S Ma*. SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma. Nat Commun. 2023 Nov 29;14(1):7863.
- HJ Yu, L Zhou*, JHC Loong, KH Lam, TL Wong, KY Ng, M Tong, VWS Ma, YY Wang, X Zhang, TKW Lee, JP Yun, J Yu, S Ma*. SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/ β-catenin signaling. Hepatology. 2023 Dec 1;78(6):1711-1726.
- L Zhou, S Ma. Deciphering cancer stem cells in liver cancers: new tools with improved resolution. Carcinogenesis. 2022 May 19;43(4):297-300.
- L Zhou†, KHO Yu†, TL Wong†, Z Zhang, CH Chan, JHC Loong, N Che, HJ Yu, KV Tan, ESW Ngan, JWK Ho*, S Ma*. Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumor-propagating cells and their dynamic cellular transition during liver cancer progression. Gut. 2022 Aug;71(8):1656-1668.
- LH Chan†, L Zhou†, KY Ng†, TL Wong†, TK Lee, R Sharma, JHC Loong, YP Ching, YF Yuan, D Xie, CM Lo, K Man, B Artegiani, H Clevers, HH Yan, SY Leung, S Richard, XY Guan, MS Huen, S Ma. Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation. Cell Reports. 2018 Oct 16;25(3):690-701.
- L Zhou†, SL Ma†, PKK Yeung, YH Wong, KWK Tsim, KF So, LCW Lam, SK Chung. Anxiety and depression with neurogenesis defect in Exchange Protein Directly Activated by cAMP (Epac) 2-deficient mice are ameliorated by selective serotonin reuptake inhibitor, Prozac. Translational Psychiatry. 2016 Sep 6;6(9): e881.
