
个人简介
2016年博士毕业于清华大学医学院生物系,2017-2022年于美国德州大学MD安德森癌症中心从事博士后研究工作,2023年入选中山大学“百人计划”引进人才并任职中山大学附属第一医院精准医学研究院。主要研究肝癌靶向治疗新靶点和生物标志物、肝癌肿瘤微环境的免疫耐受机制、肿瘤相关信号通路的调控机制等。代表性论文发表在Journal of Hepatology, Gastroenterology, Journal of Biological Chemistry等国际知名杂志。
代表性成果
- C Liu#, Z Zha#, C Zhou#, Y Chen, W Xia, Y Wang, H Lee, Y Yin, C Chang, L Chan, Y Qiu, H Li, C Li, J Hsu, J Hsu, S Wang, N Ren and MC Hung. Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma. J Hepatol. 2021. 74(4): P907-918. (IF: 30.083)
- C Zhou#, J Weng#, C Liu#, S Liu, Z Hu, X Xie, D Gao, Q Zhou, J Sun, R Xu, H Li, Y Shen, Y Yi, Y Shi, X Sheng, Q Dong, MC Hung, N Ren. Disruption of SLFN11 Deficiency-Induced CCL2 Signaling and Macrophage M2 Polarization Potentiates Anti-PD-1 Therapy Efficacy in Hepatocellular Carcinoma. Gastroenterology. 2023.2 (28)S0016-5085(23)00137-3. (IF: 33.883)
- C Liu#, Y Zhou#, M Li, Y Wang, L Yang, S Yang, Y Feng, Y Wang, Y Wang, F Ren, J Li, Z Dong, Y Chin, X Fu, L Wu and ZJ Chang. Absence of GdX/UBL4A protects against inflammatory diseases by regulating NF-κB signaling in macrophages and dendritic cells. Theranostics. 2019. 9 (5), 1369. (IF: 11.6)
- C Liu, Y Zhang, J Li, Y Wang, F Ren, Y Zhou, Y Wu, Y Feng, Y Zhou, F Su, B Jia, D Wang, ZJ Chang. p15RS/RPRD1A (p15INK4brelated sequence/regulation of nuclear pre-mRNA domain-containing protein 1A) interacts with HDAC2 in inhibition of the Wnt/beta-catenin signaling pathway. J Biol Chem. 2015. 290: 9701-13. (IF: 5.5)
- C Zhou#, C Liu#, W Liu#, Y Yin, C Li, J Hsu, J Sun, Q Zhou, H Li, B Hu, P Fu, M Atyah, Q Ma, Y Xu, Q Dong, MC Hung and N Ren. SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway. Theranostics. 2020.10 (10), 4627. (IF: 11.6)
- C Zhou#, J Weng#, C Liu#, Q Zhou, W Chen, J Hsu, J Sun, M Atyah, Y Xu, Y Shi, Y Shen, Q Dong, MC Hung and N Ren. High RPS3A expression correlates with low tumor immune cell infiltration and unfavorable prognosis in hepatocellular carcinoma patients. Am J Cancer Res. 2020. 10(9): 2768–2784. (IF: 6.166)
团队介绍
课题组长期聚焦肿瘤治疗新靶点的鉴定和以生物标志物为指导的个性化精准治疗,阐明新靶点在与肿瘤发生和与免疫细胞功能调控相关的细胞信号传导通路中的作用机制。致力于探索肿瘤靶向治疗和免疫疗法中产生抵抗的潜在分子机制,进而开发新疗法重塑抑制性免疫微环境。
招生招聘
本课题组依托中山大学附属第一医院精准医学研究院正在致力于组建一支高水平的研究队伍,课题方向多元,且已有扎实的前期研究基础,与领域内多个知名专家有长期深入合作。期待有科研热情的研究生和科研助理加入。