中山大学“百人计划”人才引进，长期致力于消化系统肿瘤机制和防治研究，目前研究方向以消化系统肿瘤表观遗传学为主，近年来以第一作者身份在Gut、Gastroenterology、Clin Cancer Res、Cancer Res、Oncogene等国际高水平期刊发表多篇研究性文章。

Wang’s lab focuses on the role of dysregulation of RNA epigenetics (m6A, ac4c and etc.) in cancer and its clinical impact by utilizing multiple approaches including low-input RNA modification RIP-seq, transgenic mice, organoids and multiomics.

1. Wang S#, Huang J#, Li C, Zhao L, Wong CC, Zhai J, Zhou Y, Deng W, Zeng Y, Gao S, Zhang Y, Wang G, Guan XY, Wei H, Wong SH, He HH, Shay JW, Yu J. MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer. Clin Cancer Res. 2020 Feb 1;26(3):746-757.

2. Wang S#, Gao S#, Zeng Y#, Zhu L, Mo Y, Wong CC, Bao Y, Su P, Zhai J, Wang L, Soares F, Xu X, Chen H, Hezaveh K, Ci X, He A, McGaha T, O'Brien C, Rottapel R, Kang W, Wu J, Zheng G, Cai Z, Yu J, He HH. N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer. Gastroenterology. 2022 Apr;162(4):1183-1196. doi: 10.1053/j.gastro.2021.12.269. Epub 2021 Dec 28. PMID: 34968454.

3. Wang S#, Zhang Y#, Huang J, Wong CC, Zhai J, Li C, Wei G, Zhao L, Wang G, Wei H, Zhao Z, Yu J. TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression. Cancer Res. 2019 Aug 15;79(16):4086-4098.

4. Wang S, Wong CC, Zhang Y, Huang J, Li C, Zhai J, Wang G, Wei H, Zhang X, He HH, Yu J. ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice. Oncogene. 2021 Dec;40(48):6590-6600. doi: 10.1038/s41388-021-01938-8. Epub 2021 Oct 6. PMID: 34615997; PMCID: PMC8639438.

5. Wang S, Cheng Y, Du W, Lu L, Zhou L, Wang H, Kang W, Li X, Tao Q, Sung JJ, Yu J*. Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer. Gut. 2013 Jun;62(6):833-41.

6. Wang S#, Dong Y#, Zhang Y#, Wang X, Xu L, Yang S, Li X, Dong H, Xu L, Su L, Ng SS, Chang Z, Sung JJ, Zhang X*, Yu J*. DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer. Oncogene. 2015 May 14;34(20):2575-85.

7. Zeng Y#, Wang S#, Gao S, Soares F, Ahmed M, Guo H, Wang M, Hua JT, Guan J, Moran MF, Tsao MS, He HH*. Refined RIP-seq protocol for epitranscriptome analysis with low input materials. PLoS Biol. 2018 Sep 13;16(9):e2006092.