夏文敏
副研究员，博士生导师
研究方向：脂肪细胞生物学与肥胖等代谢性疾病的关系
电子邮件： xiawm@mail.sysu.edu.cn
个人简介

副研究员，博士生导师，2024年入选中山大学“百人计划”中青年杰出人才。2015-2018年于奥地利格拉茨技术大学生物化学系和美国加州大学圣地亚哥分校医学院学习，取得奥地利授予的自然科学博士学位。期间获得奥地利政府颁发的马歇尔计划奖学金。2018-2024年于美国加州大学圣地亚哥分校从事博士后研究工作。主要研究方向为脂肪细胞生物学与肥胖等代谢性疾病的关系，本课题组致力于脂肪细胞功能障碍的分子机制及其在肥胖、非酒精性脂肪肝和癌症等代谢紊乱疾病中的作用。重点关注脂肪细胞内的各类代谢通路对线粒体功能和形态动力学的影响与作用机制。代表性研究工作发表在Nature Metabolism, Cell Reports, Diabetes, Nature Communications, Proceedings of National Academy of Sciences等知名杂志。

研究方向

1、代谢紊乱对线粒体形态动力学的影响与机制

2、脂肪细胞分泌的代谢产物对细胞间通讯的影响与机制

3、脂肪细胞功能障碍对机体胰岛素抵抗的影响与机制

团队介绍

课题组处于快速发展阶段，课题组负责人高度支持每个成员的职业发展和个人成长需求，努力营造高效、和谐的团队合作氛围，鼓励成员保持积极、乐观的生活和工作态度。

招生招聘

课题组长期招收博士后、博士/硕士研究生和研究助理/助手，热忱欢迎对脂肪细胞生物学、糖脂代谢、线粒体功能、组织器官间通讯研究有浓厚兴趣的同学加入。

代表性成果
  1. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne T, Qian J, Hung C, Zhao P, Jones Y, Gao H, Liddle C, Yu R, Downes M, Evans R, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly S, Huang J, Saltiel A. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nature Metabolism 2024, DOI: 10.1038/s42255-024-00978-0
  2. Xia W#, Pessentheiner A#, Hofer D, Amor M, Schreiber R, Schoiswohl G, Eichmann T, Walenta E, Itariu B, Prager G, Hackl H, Stulnig T, Kratky D, Rülicke T, Bogner-Strauss J. Loss of ABHD15 impairs the anti-lipolytic action of insulin by altering PDE3B stability and contributes to insulin resistance. Cell Reports 2018 May 15;23(7):1948-1961. DOI: 10.1016/j.celrep.2018.04.055.
  3. Luan D, Dadpey B, Zaid J, Bridge-Comer P, DeLuca J, Xia W, Castle J, Reilly S. Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling. Diabetes 2023, DOI: 10.2337/db22-0444
  4. Huang J, Linares J, Duran A, Xia W, Saltiel A, Müller T, Diaz-Meco M, Moscat J. NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ. Nature Communications 2021, DOI: 10.1038/s41467-021-23085-0
  5. Hofer D, Zirkovits G, Pelzmann H, Huber K, Pessentheiner A, Xia W, Kyosuke K, Miyazaki T, Kon K, Tsuneki H, Pendl T, Zoughbi W, Madreiter-Sokolowski C, Trausinger G, Abdellatif M, Schoiswohl G, Schreiber R, Eisenberg T, Magnes C, Sedej S, Eckhardt M Sasahara M, Sasaoka T, Nitta A, Hoefler G, Graier W, Kratky D, Auwerx J, Bogner-Strauss JG. N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health. FASEB journal 2019, DOI: 10.1096/fj.201801323R
  6. Skorobogatko Y, Dragan M, Cordon C, Reilly S, Hung CW, Xia W, Zhao P, Wallace M, Lackey D, Chen X, Osborn O, Bogner-Strauss J, Theodorescu D, Metallo C, Olefsky J, Saltiel A. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. PNAS 2018, DOI: 10.1073/pnas.1801050115
  7. Duta-Mare M, Sachdev V, Leopold C, Kolb D, Vujic N, Korbelius M, Hofer D, Xia W, Huber K, Auer M, Gottschalk B, Magnes C, Graier W, Prokesch A, Radovic B, Bogner-Strauss J, Kratky D. Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis. Biochim Biophys Acta-Mol Cell Biol Lipids 2018, DOI: 10.1016/j.bbalip.2018.01.011
  8. Zheng H, Dong X, Liu N, Xia W, Zhou L, Chen X, Yang Z, Chen X. Regulation and mechanism of mouse miR-130a/b in metabolism-related inflammation. Int J Biochem Cell Biol 2016, DOI: 10.1016/j.biocel.2016.02.021

 

相关研究成果的专家评议：

  1. Zambello, L., Scorrano, L. A RalA between high-fat diet and mitochondrial shape. Nat Metab 6, 198–199 (2024). https://doi.org/10.1038/s42255-023-00969-7
  2. Legg, K. RalA links obesity and mitochondrial dysfunction. Nat Rev Endocrinol 20, 193 (2024). https://doi.org/10.1038/s41574-024-00962-4
  3. https://www.nih.gov/news-events/nih-research-matters/obesity-disrupts-mitochondria-reduces-fat-burning