本科（2013）和硕士（2016）毕业于中山大学，博士毕业于香港中文大学（2019）。主要致力于消化道肿瘤免疫微环境的研究，包括肝癌、胆管癌、肠癌肝转移瘤在发生发展和进展过程中肿瘤免疫微环境的重塑和调控机制、治疗后复发的相关机理和转化研究。

1. H. Liu^#, X. Zeng^#, X. Ren^#, Y. Zhang^#, M. Huang^#, et al., Targeting tumour-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy. Gut. 2023. 72(8): p. 1555-1567.
2. X. Zeng^#, G. Liao^#, S. Li^#, H. Liu, X. Zhao, S. Li, et al., Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents HCC recurrence after radiofrequency ablation. Hepatology, 2023. 77(4): p. 1122-1138.
3. Peng, S^#., S. L. Chen^#, W. Hu^#, J. Mei^#, X. Zeng^#, et al., Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma. Cancer Immunology Research. 2022. 10(6): p. 728-744.
4. X. Zeng, J. Zhou, Z. Xiong, H. Sun, W. Yang, et al., Cell cycle-related kinase reprograms liver immune microenvironment to promote cancer metastasis. Cell. Mol. Immunol. 2020. 18(4): p. 1005-1015.
5. H. Sun^#, W. Yang^#, Y. Tian^#, X. Zeng^#, et al., An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. Nat. Commun. 2018. 9(1): p.5214.
6. X. Zeng, X. Li, C. Xu, F. Jiang, Y. Mo, et al., Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. Acta Pharm Sin B. 2017. 7(5): p. 583-592.

1. 2024-2026，柯麟新锐人才项目，主持。
2. 2024-2027，国家自然科学基金面上项目，主持。
3. 2020-2022，国家自然科学基金青年项目，主持，已结题。

团队由博士后、研究生和研究助理组成，拥有临床医学、肿瘤学、免疫学背景。课题组主要致力于的研究，利用临床标本和小鼠标本进行单细胞转录组，空间转录组，翻译组等多组学分析，挖掘调控肝胆肿瘤免疫抑制微环境调控机制及治疗策略。