国家级高层次青年人才项目获得者;中山大学“百人计划”中青年杰出人才引进人才,博士生导师,博士后合作导师。于2018年在中山大学生命科学学院获得博士学位. 随后哈佛医学院/丹娜法伯(Dana-Farber)癌症研究中心从事博士后研究(2019-2022),并于2022年晋升为哈佛医学院讲师(2022-2025)。近年来以独立第一或通讯作者在Molecular Cell (2018,2020),Cell Reports(2022),Nature Communication (2025), PNAS(2026)等高水平杂志发表多篇高水平研究论文。
课题组聚焦基因组不稳定性驱动肿瘤发生与衰老进程的分子机制,通过解析DNA损伤修复、异染色质组装、端粒稳态等关键通路,揭示其如何通过促进突变累积、细胞周期紊乱及炎症反应,同时推动肿瘤恶性转化与组织功能衰退。研究特色在于整合基础机制探索与转化医学应用,为癌症治疗和抗衰老干预提供新靶点。
- Li F*, Elbakry A, Zhou F, Zhang T, Ravindranathan R, Nguyen H, Syed A, Sun L, Mukkavalli S, Greenberg R, D’Andrea A*. CHAMP1 Complex Promotes Heterochromatin Assembly and Reduces Replication Stress. PNAS. 2026 Jan 6;123(1). PMID: 41481470. (*corresponding author)
- Li F*, Zhang T, Syed A, Elbakry A, Holmer N, Nguyen H, Mukkavalli S, Greenberg R, D’Andrea A*. CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair. Nature Communications. 2025 Feb 17;16(1):1714. PMID: 39962076. (*corresponding author)
- Li F, Sarangi P, Iyer D, Feng H, Moreau L, Nguyen H, Clairmont C, D’Andrea A. CHAMP1 binds to REV7/FANCV and Promotes Homologous Recombination Repair. Cell Reports. 2022 Aug 30;40(9):111297. PMID: 36044844.
- Li F, Kozono D, Deraska P, Branigan T, Dunn C, Zheng X, Parmar K, Nguyen H, DeCaprio J, Shapiro. G, Chowdhury D, D’Andrea A. CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Molecular Cell. 2020 Nov 5;80(3):410-422.e6. PMID: 33108758. (Cover story of the issue)
- Li F, Ge Y, Liu D, Songyang Z. The role of telomere-binding modulators in pluripotent stem cells. Protein & Cell. 2020 Jan;11(1):60-70. PMID: 31350723. (Review)
- Luo Z*, Wang W*, Li F*, Songyang Z, Feng X, Xin C, Dai Z, Xiong Y. Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes. Molecular Cancer. 2019 Jun 10;18(1):106. PMID: 31179925. (*co-first author)
- Li F, Kim H, Ji Z, Zhang T, Chen B, Ge Y, Hu Y, Feng X, Han X, Xu H, Zhang Y, Yu H, Liu D, Ma W, Songyang Z. The BUB3-BUB1 Complex Promotes Telomere DNA Replication. Molecular Cell. 2018 May 3; 70(3):395-407. PMID: 29727616.
曾主持美国Claudia Adams Barr创新癌症研究项目(约220万元)
- Li F (2025). CHAMP1 Complex Promotes Heterochromatin Assembly and Reduces Replication Stress. isDDRHD-2025: 16th International Symposium on DNA Damage Response and Human Disease, Qingdao, China.
- Li F (2025). Molecular Pathogenesis of the CHAMP1 Syndrome and its relationship to the Fanconi Anemia/BRCA Pathway. 37th annual Fanconi Cancer Foundation Scientific Symposium, Minneapolis, MN, USA.
- Li F (2024). Spatial Regulation of the CHAMP1 complex in promoting Double-Strand Break Repair. ATW-2024/isDDRHD-2024, Shenzhen, China.
- Li F (2024). CHAMP1 Complex Directs Telomere Heterochromatin Assembly during Alternative Lengthening of Telomere. Longwood Area DNA Damage and Repair Seminar (LADDAR), Boston, MA, USA.
- Li F (2022). The regulation of DNA repair pathway choice. Columbia University Social DNAing Seminar Series, New York, USA (Virtual).
奖励荣誉:
Claudia Adams Barr Research Award
编审期刊:
Nature Communication, Nucleic Acids Research, Journal of Cell Science, Cell Death & Disease, iScience等。
学术兼职:
客座编辑:Frontiers in Oncology,Frontiers in Cell and Developmental Biology。
计划招收3-4名博士后、每年招收至少1名博士/硕士研究生、以及数名研究助理、科研助手。课题组具有较好的前期基础,和前沿的科学研究方向,并拥有充足的科研经费和一流的科研设施与优越的工作环境。与哈佛医学院丹娜法伯癌症中心, 宾夕法尼亚大学,弗吉尼亚大学等国际一流高校保持长期合作,可为成员提供海外交流与参加国际学术会议的机会。欢迎对科学研究有浓厚兴趣的同学加入,请将简历发送到邮箱: lifeng48@mail.sysu.edu.cn